Complaints That Suspect Actos Side Effects


Oct 1, 2012
Actos has been issued a label warning by the FDA stating the risk of bladder cancer in using this drug. It specifically stated, in a drug safety advisory dated August 5, 2011, that patients under Actos medication for over a year are of greater risk of developing bladder cancer. It also admonished healthcare providers to refrain prescribing the drug to individuals who have a history of bladder cancer or symptoms. Symptoms of such conditions are blood in urine, pain while urinating, and pain in the lower abdomen. A brand name for the generic pioglitazone, Actos is an oral diabetes drug under distributionin the U.S. market by Takeda and Eli Lilly pharmaceuticals. Approved by the FDA in 1999, the drug helps regulate blood sugar levels in individuals suffering from Type 2 diabetes. Though studies spearheaded by its manufacturer has claimed that the drug has helped decrease the number of diabetes sufferers by 72 percent, the fact remains that the Actos side effects outweigh the drug’s benefits. Actos has been found to have a link to several fatal side effects. These include fluid retention and cardiovascular problems. In a 2003 Mayo Clinic research study, a link between Actos and swelling in the feet, fluid retention in the lungs, shortness of breath, and congestive heart failure have been concluded. Thus, the FDA came up with a directive for a comprehensive review of the drug safety in September 2010.The study, which spans over a 10-year period, found that bladder cancer risk in diabetes patients under Actos medication was greater in comparison to other drugs. In fact, the risk was of greater statistical significance in individuals under Actos medication for over 24 months. In February 2007, Takeda came to the admission that the drug is potentially risky to female diabetics because of greater risk of limb (e.g. hand, arm, foot) fractures. This confession came following the ADOPT tests done by GlaxoSmithKline for its diabetes drug Avandia. Additionally, a research report presented at the American Diabetes Association meet at San Diego in June 2011, stated that Actos increases the risk of diabetic macular edema by 3 to 6 percent. This is because the drug causes thickening and swelling of retina, which ultimately leads to blindness. The research came to conclusion after studying more than 100,000 diabetics. Furthermore, a report appearing in the August 2010 issue of the American Heart Association Journal, Actos also increases the probability of cardiovascular problems or fatal consequences. This study involves 36,000 diabetes patients taking Avandia and Actos in the span of between 12 to 14 months. It was able to establish cardiovascular problems and deaths brought by congestive heart failure in both medication groups. Thus, the FDA was prompted to come up with a mandatory black box warning for heart failure on Actosin June 2007. Aside from carrying boxed warning for congestive heart failure, Actos also carries separate label warnings for edema and fractures. The adverse effects of the medication cause congestive heart failure, high blood pressure, bladder cancer, body pain, and behavioral changes. With the surprising number of Actos side effects, a proportionate rise in Actos lawsuits is not far from happening. Share Bookmark on Delicious Recommend on Facebook Buzz it up Share on Linkedin Share via MySpace Share on Orkut share via Reddit Share on identica Share with Stumblers Share on technorati Tumblr it Tweet about it Print for later Bookmark in Browser